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1.

106981
Accesses

Review   Open Access Highly Accessed

A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States

Renee Dufault, Walter J Lukiw, Raquel Crider, Roseanne Schnoll, David Wallinga, Richard Deth Clinical Epigenetics 2012, 4:6 (10 April 2012)

Abstract | Full text | PDF | PubMed

2.

5884
Accesses

Review   Open Access Highly Accessed

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells

Praveen Rajendran, Emily Ho, David E Williams, Roderick H Dashwood Clinical Epigenetics 2011, 3:4 (26 October 2011)

Abstract | Full text | PDF | PubMed

3.

4680
Accesses

Review   Open Access Highly Accessed

Epigenetic (de)regulation of adult hippocampal neurogenesis: implications for depression

António Mateus-Pinheiro, Luísa Pinto, Nuno Sousa Clinical Epigenetics 2011, 3:5 (1 November 2011)

Abstract | Full text | PDF | PubMed

4.

4159
Accesses

Research   Open Access Highly Accessed

Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells

Anna Hsu, Carmen P Wong, Zhen Yu, David E Williams, Roderick H Dashwood, Emily Ho Clinical Epigenetics 2011, 3:3 (26 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

5.

4086
Accesses

Review   Open Access Highly Accessed

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

Geneviève P Delcuve, Dilshad H Khan, James R Davie Clinical Epigenetics 2012, 4:5 (12 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

6.

2944
Accesses

Research   Open Access Highly Accessed

The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring

A Soubry, SK Murphy, Z Huang, A Murtha, JM Schildkraut, RL Jirtle, F Wang, J Kurtzberg, W Demark-Wahnefried, MR Forman, C Hoyo Clinical Epigenetics 2011, 3:2 (26 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Maternal anti-depressant use is associated with increased DNA methylation in the newborns of African American but not Caucasian mothers, potentially affecting their health status in later life.

7.

2888
Accesses

Research   Open Access Highly Accessed

Variation in ultraviolet radiation and diabetes: evidence of an epigenetic effect that modulates diabetics’ lifespan

George E Davis, Walter E Lowell Clinical Epigenetics 2013, 5:5 (2 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

2774
Accesses

Research   Open Access Highly Accessed

Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects

Olivier J Switzeny, Elisabeth Müllner, Karl-Heinz Wagner, Helmut Brath, Eva Aumüller, Alexander G Haslberger Clinical Epigenetics 2012, 4:19 (1 October 2012)

Abstract | Full text | PDF | PubMed

9.

2590
Accesses

Editorial   Open Access

Clinical Epigenetics is now a fully open access journal

Ulrich Mahlknecht Clinical Epigenetics 2011, 3:1 (26 October 2011)

Abstract | Full text | PDF | PubMed

10.

2525
Accesses

Review   Open Access

On the epigenetics of vascular regulation and disease

Christina Schleithoff, Susanne Voelter-Mahlknecht, Indra Dahmke, Ulrich Mahlknecht Clinical Epigenetics 2012, 4:7 (23 May 2012)

Abstract | Full text | PDF | PubMed

11.

2496
Accesses

Review   Open Access

The epigenetic effects of butyrate: potential therapeutic implications for clinical practice

Roberto Berni Canani, Margherita Di Costanzo, Ludovica Leone Clinical Epigenetics 2012, 4:4 (27 February 2012)

Abstract | Full text | PDF | PubMed

12.

2400
Accesses

Review   Open Access

Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics

Takeo Kubota, Kunio Miyake, Takae Hirasawa Clinical Epigenetics 2012, 4:1 (20 January 2012)

Abstract | Full text | PDF | PubMed

13.

2151
Accesses

Research   Open Access

LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes

Valérie Turcot, André Tchernof, Yves Deshaies, Louis Pérusse, Alexandre Bélisle, Simon Marceau, Simon Biron, Odette Lescelleur, Laurent Biertho, Marie-Claude Vohl Clinical Epigenetics 2012, 4:10 (2 July 2012)

Abstract | Full text | PDF | PubMed

14.

2127
Accesses

Review   Open Access

Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix

Kathleen P Saavedra, Priscilla M Brebi, Juan Carlos S Roa Clinical Epigenetics 2012, 4:13 (31 August 2012)

Abstract | Full text | PDF | PubMed

15.

2004
Accesses

Review   Open Access Highly Accessed

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

Metin Karahoca, Richard L Momparler Clinical Epigenetics 2013, 5:3 (1 February 2013)

Abstract | Full text | PDF | PubMed

16.

1983
Accesses

Research   Open Access

The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years

Nelís Soto-Ramírez, Syed Hasan Arshad, John W Holloway, Hongmei Zhang, Eric Schauberger, Susan Ewart, Veeresh Patil, Wilfried Karmaus Clinical Epigenetics 2013, 5:1 (3 January 2013)

Abstract | Full text | PDF | PubMed

17.

1754
Accesses

Research   Open Access

BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer

Eddy H van Roon, Arnoud Boot, Ashwin A Dihal, Robert F Ernst, Tom van Wezel, Hans Morreau, Judith M Boer Clinical Epigenetics 2013, 5:2 (16 January 2013)

Abstract | Full text | PDF | PubMed

18.

1737
Accesses

Review   Open Access

DNA promoter methylation as a diagnostic and therapeutic biomarker in gallbladder cancer

Pablo Letelier, Priscilla Brebi, Oscar Tapia, Juan Roa Clinical Epigenetics 2012, 4:11 (13 July 2012)

Abstract | Full text | PDF | PubMed

19.

1714
Accesses

Research   Open Access

A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis

Mansi A Parasramka, W Dashwood, Rong Wang, Hassaan H Saeed, David E Williams, Emily Ho, Roderick H Dashwood Clinical Epigenetics 2012, 4:16 (24 September 2012)

Abstract | Full text | PDF | PubMed

20.

1650
Accesses

Hypothesis   Open Access

Milk kinship hypothesis in light of epigenetic knowledge

Hasan Ozkan, Funda Tuzun, Abdullah Kumral, Nuray Duman Clinical Epigenetics 2012, 4:14 (18 September 2012)

Abstract | Full text | PDF | PubMed

21.

1570
Accesses

Research   Open Access

Hypermethylation of the 5′ CpG island of the p14 ARF flanking exon 1β in human colorectal cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression

Christine Nyiraneza, Christine Sempoux, Roger Detry, Alex Kartheuser, Karin Dahan Clinical Epigenetics 2012, 4:9 (15 June 2012)

Abstract | Full text | PDF | PubMed

22.

1515
Accesses

Research   Open Access

Delivery type not associated with global methylation at birth

Shama Virani, Dana C Dolinoy, Sindhu Halubai, Tamara R Jones, Steve E Domino, Laura S Rozek, Muna S Nahar, Vasantha Padmanabhan Clinical Epigenetics 2012, 4:8 (9 June 2012)

Abstract | Full text | PDF | PubMed

23.

1507
Accesses

Research   Open Access

Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children

Arunima Kohli, Marco A Garcia, Rachel L Miller, Christina Maher, Olivier Humblet, S Hammond, Kari Nadeau Clinical Epigenetics 2012, 4:17 (25 September 2012)

Abstract | Full text | PDF | PubMed

24.

1497
Accesses

Research   Open Access

DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults

Rae-Chi Huang, John C Galati, Sally Burrows, Lawrence J Beilin, Xin Li, Craig E Pennell, JAM van Eekelen, Trevor A Mori, Leon A Adams, Jeffrey M Craig Clinical Epigenetics 2012, 4:21 (13 November 2012)

Abstract | Full text | PDF | PubMed

25.

1451
Accesses

Methodology   Open Access

A systematic evaluation of whole genome amplification of bisulfite-modified DNA

Miki Bundo, Fumiko Sunaga, Junko Ueda, Kiyoto Kasai, Tadafumi Kato, Kazuya Iwamoto Clinical Epigenetics 2012, 4:22 (22 November 2012)

Abstract | Full text | PDF | PubMed

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